花芳，1977年生，籍贯福建，药物研究所研究员，博士生导师。1995年考入复旦大学临床医学专业，2000年获医学学士学位。本科毕业后进入中国协和医科大学生物化学与分子生物学专业硕博连读，获得理学博士学位。2005年进入北京协和医学院药物研究所工作，主要从事肿瘤药理相关研究。2017-2019年作为访问学者在密歇根大学医学院从事肿瘤免疫相关研究。2014年晋升副研究员，2018年晋升研究员。2021年07月获聘北京协和医学院准聘副教授。

肿瘤对代谢因素的适应性以及肿瘤本身的代谢方式改变是肿瘤研究的核心和重点。花芳团队一直从事肿瘤代谢与癌基因信号、以及肿瘤免疫微环境的交叉反馈调节机制、药靶寻找以及干预策略研究。

1. Shang S^#, Yang YW^#, Chen F^#, Yu L, Shen SH, Li K, Cui B, Lv XX, Zhang C, Yang C, Liu J, Yu JJ, Zhang XW, Li PP, Zhu ST, Zhang HZ*, Hua F*. TRIB3 Reduces CD8⁺ T Cell Infiltration and Induces Immune Evasion by Repressing the STAT1-CXCL10 Axis in Colorectal Cancer. Sci Transl Med 2022, 14(626):eabf0992. (IF=19.359)

2. Li K^#*, Zhang TT^#, Zhao CX^#, Wang F, Cui B, Yang ZN, Lv XX, Yeerjiang Z, Yuan YF, Yu JM, Wang ZH, Zhang XW, Yu JJ, Liu SS, Shang S, Huang B, Hua F*, Hu ZW*. Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability. Sci Transl Med 2021, 13(586):eabb2914. (IF=19.359)

3. Du W^#, Hua F^#, Li X, Zhang J, Li S, Wang W, Zhou J, Wang W, Liao P, Yan Y, Li G, Wei S, Grove S, Vatan L, Zgodzinski W, Majewski M, Wallner G, Chen H, Kryczek I, Fang JY, Zou W*. Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation. Cancer Discov, 2021, 11(7): 1826-1843. (IF=38.272)

4. Yu JJ^#, Zhou DD^#, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F*, Hu ZW*; TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target. Nat Commun, 2020, 11(1): 3660. (IF=14.919)

5. Yu JJ^#, Zhou DD^#, Cui B, Zhang C, Tan FW, Chang S, Li K, Lv XX, Zhang XW, Shang S, Xiang YJ, Chen F, Yu JM, Liu SS, Wang F, Hu ZW*, Hua F*. Disruption of the EGFR-SQSTM1 interaction by a stapled peptide suppresses lung cancer via activating autophagy and inhibiting EGFR signaling. Cancer Lett 2020, 474:23-35. (IF=8.679)

6. Hua F^#, Shang S^#, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW*. TRIB3 Interacts with Beta-catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology 2019, 156(3):708-721. (IF=17.373)

7. Li K^#, Zhang TT^#, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F*, Hu ZW*. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene 2018, 37(22):2967-2981. (IF=6.634)

8. Hua F^#, Li K^#, Yu JJ^#, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun 2015, 6:7951. (IF=11.329, C100)

9. Hua F^#, Shi MJ^#, Zhu XL^#, Li M, Wang HX, Yu XM, Li Y, Zhu CJ*. Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance. Biochem Pharmacol 2015, 98:224-230. (IF=5.091)

10. Hua F^#, Mu R^#, Liu JW, Xue JF, Wang ZY, Lin H, Yang HZ, Chen XG, Hu ZW*. TRB3 interacts with SMAD3 promoting tumor cell migration and invasion. J Cell Sci, 124:3235-3246, 2011. (IF: 6.111, C100)