陈厚早，1978年生，安徽肥西人，基础医学研究所研究员，博士生导师。2001年在蚌埠医学院获得大学本科学位，2004年在安徽医科大学获得硕士学位，同年在中国协和医科大学生物化学与分子生物学专业攻读博士学位，2007年博士毕业后留中国医学科学院基础医学院所从事心血管疾病的表观遗传机制研究。2011年升为副研究，2013年被破格为博士生导师，2018年升为研究员。

衰老相关心血管疾病的基础研究，系统地阐述了表观遗传修饰酶SIRTuin家族等在心血管疾病中的作用，表明其可为防治心血管疾病的潜在靶点，论文被引用3800余次，H-index 35；获2次F1000 推荐，Nat Cell Biol等5次杂志同期评论。

1. Zheng W#*, Wang X#*, Liu J#, Yu X#, Li L, Wang H, Yu J, Pei X, Li C, Wang Z, Zhang M, Zeng X, Zhang F, Wang C, Chen H, Chen HZ*. Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Behçet's disease. Proc Natl Acad Sci USA. 2022 28;119(26):e2204289119. (IF=12.779)

2. Wang X#*, Ma L#, Pei X#,Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP*, Chen HZ*. Comprehensive assessment of cellular senescence in the tumor microenvironment. Brief Bioinform. 2022 May 13;23(3):bbac118. (IF=13.994)

3. XiaoqiangTang#,Xiao-Feng Chen#,Xin Sun#,Peng Xu,Xiang Zhao,Ying Tong,Xiao-Man Wang,Ke Yang,Yu-Tong Zhu,De-Long Hao,Zhu-Qin Zhang,De-Pei Liu*,Hou-Zao Chen*.Short-Chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis. Circulation. 2021 Mar 9;143(10):1066-1069. (IF=29.69)

4. Jian-Fei Pei#,Xun-Kai Li#,Wen-Qi Li#, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S Carroll,Jing Yang, Eric Erquan Zhang,Ji-Min Cao, Hou-Zao Chen*,De-Pei Liu*.Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks. Nat Cell Biol. 2019 Dec;21(12):1553-1564. (IF=28.824)

5. Xiaoqiang Tang#, Xiao-Feng Chen#, Nan-Yu Wang, Xiao-Man Wang, Shu-Ting Liang, Wei Zheng, Yun-Biao Lu, Xiang Zhao, De-Long Hao, Zhu-Qin Zhang, Ming-Hui Zou, De-Pei Liu*, Hou-Zao Chen*.SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. Circulation. 2017 Nov 21;136(21):2051-2067.  (IF=29.69, F1000)

6. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J.2017 May 7;38(18):1389-1398. (IF=29.983,C100)

7. Yue Liu#, Ting-Ting Wang#, Ran Zhang#, Wen-Yan Fu, Xu Wang, Fang Wang, Peng Gao, Yang-Nan Ding, Yan Xie, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016 Oct 17;213(11):2473-2488. (IF=14.307)

8. Hou-Zao Chen#, Fang Wang#, Peng Gao#, Jian-Fei Pei#, Yue Liu, Ting-Ting Xu, Xiaoqiang Tang, Wen-Yan Fu, Jie Lu, Yun-Fei Yan, Xiao-Man Wang, Lei Han, Zhu-Qin Zhang, Ran Zhang, Ming-Hui Zou, De-Pei Liu*.Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ Res. 2016 Oct 28;119(10):1076-1088. (IF=17.367,C100)