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药物研究所

个人简介

耿轶群,1983年生,籍贯河南,化学生物学家,药物所研究员,博士生导师。2001年考入北京大学药学专业,2005年获得学士学位。2005-2007年在北京大学药学院化学生物学专业攻读硕士学位,从事糖化学研究。2007-2011年在北京大学药学院化学生物学专业攻读博士学位,从事糖化学生物学研究。2011-2019年在德国康斯坦茨大学化学系和英国牛津大学化学系进行博士后研究工作,主要研究糖化学生物学和糖类药物。2010年聘为研究员/助理教授。


主要研究方向

以攻克威胁人类健康的重大疾病为导向,以探索和调控内源性糖类活性物质在生理、病理过程中的关键作用为核心科学问题,利用化学生物学手段,为相关疾病提供新的诊治靶标和先导化合物类型,驱动糖类创新药物研究。


代表性成果

1. Yingxin Shi#, Sheng Yan, Guang-Can Shao, Jinglong Wang, Yong-Ping Jian, Bo Liu, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng-Qiu Dong, Yiqun Geng*, Zhi-Xiang Xu*, Jing Li*. O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection. J. Biol. Chem. 2022, doi: 10.1016/j.jbc.2022.102341. (IF=5.486)

2. Cara A. Griffiths#, Ram Sagar#, Yiqun Geng#, Lucia F. Primavesi, Mitul K. Patel, Melissa K. Passarelli, Ian S. Gilmore, Rory T. Steven, Josephine Bunch, Matthew J. Paul*, Benjamin G. Davis*. Chemical intervention in plant sugar-signalling increases yield and resilience. Nature 2016, 540 (7634), 574-578. (IF=40.137, C100, ESI)

3. Yiqun Geng#, Amit Kumar, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. Cooperative Catalysis in Glycosidation Reactions with O-Glycosyl Trichloroacetimidates as Glycsoyl Donors. Angew. Chem. Int. Ed. 2013, 52 (38), 10089-10092. (IF=11.336)

4. Yiqun Geng#, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. C-(α-d-Glucopyranosyl)-phenyldiazomethanes-irreversible inhibitors of α-glucosidase. Bioorg. Med. Chem. 2013, 21 (16), 4793-4802. (IF=2.951)

5. Yiqun Geng#, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. Organocatalysis for the Acid-Free O-Arylidenation of Carbohydrates. Eur. J. Org. Chem. 2013 (31), 7035-7040. (IF=3.154)

6. Yiqun Geng#, Qi Qin, Xin-Shan Ye*. Lewis Acids as α-Directing Additives in Glycosylations by Using 2,3-O-Carbonate-Protected Glucose and Galactose Thioglycoside Donors Based on Preactivation Protocol. J. Org. Chem. 2012, 77 (12), 5255-5270. (IF=4.564)

7. Yiqun Geng#, Xin-Shan Ye*. Additive-Controlled Stereoselective Glycosylations of Oxazolidinone-Protected Glucosamine and Galactosamine Thioglycoside Donors Based on Preactivation Protocol. Synlett 2010 (16), 2506-2512. (IF=2.447)

8. Yiqun Geng#, Li-He Zhang, Xin-Shan Ye*. Stereoselectivity investigation on glycosylation of oxazolidinone protected 2-amino-2- deoxy-D-glucose donors based on pre-activation protocol. Tetrahedron 2008, 64 (22), 4949-4958. (IF=2.897)

9. Yiqun Geng#, Li-He Zhang, Xin-Shan Ye*. Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine. Chem. Commun. 2008(5), 597-599.(IF=5.340)