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协和医院

个人简介

李太生,1963年生,籍贯河南林县,北京协和医院感染内科主任,教授,主任医师,博士生导师。1979年考入中山医学院医学专业,1984年获得学士学位。1987年在中国协和医科大学内科学专业攻读硕士学位,从事临床医学研究。2000年法国巴黎高等研究实践学院细胞与分子生物学专业攻读博士学位,从事艾滋病相关研究。1999年升为副主任医师。2004年升为主任医师。


主要研究方向

主要研究方向为艾滋病治疗与免疫重建。研究包括适宜中国国情的诊疗方案的确定与优化,艾滋病全病程中骨、心血管等慢性疾病风险因素;艾滋病免疫病理机制;雷公藤及其提取物对艾滋病慢性炎症与免疫重建的干预研究。


代表性成果

1. Chen S, Han Y, Song XJ, Li YL, Zhu T, Lu HZ, Tang XP, Zhang T, Zhao M, He Y, He SH, Wang M, Li YZ, Huang SB, Li Y, Liu J, Cao W*, Li TS*. Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART: a long-term observation in treatment-naïve patients. Infect Dis Poverty. 2020 Jun 22;9(1):75. (IF=4.388)

2.Lin L, Lu L, Cao W, Li T*. Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020;9(1):727-732. (IF=7.163,C100, ESI )

3. Cao W, Li T*. COVID-19: towards understanding of pathogenesis. Cell Res. 2020;30(5):367-369. (IF=25.617, C100)

4. Cao W, Liu X, Bai T, Fan H, Hong K, Song H, Han Y, Lin L, Ruan L, Li T*. High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients with Coronavirus Disease 2019. Open Forum Infect Dis. 2020 Mar 21;7(3):ofaa102. (IF=3.835, C100, ESI, R)

5. Taisheng Li*, Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0).[J] .Emerg Microbes Infect, 2020, 9: 582-585. (IF=7.163, R)

6.中华医学会感染病学分会艾滋病丙型肝炎学组,中国疾病预防控制中心,李太生*.中国艾滋病诊疗指南(2018年版)[J].中华内科杂志,2018,57(12):867-884.(C100)

7. Wang, HL; Ghanem, KG; Wang, P; Yang, S; Li, TS*. Listeriosis at a Tertiary Care Hospital in Beijing, China: High Prevalence of Nonclustered Healthcare-Associated Cases Among Adult Patients. CLINICAL INFECTIOUS DISEASES, 2013.56(5):666-676. (IF=8.216)

8. Li, TS*; Wu, N; Dai, Y; Qiu, ZF; Han, Y; Xie, J; Zhu, T; Li, YL. Reduced Thymic Output Is a Major Mechanism of Immune Reconstitution Failure in HIV-Infected Patients After Long-term Antiretroviral Therapy. CLINICAL INFECTIOUS DISEASES, 2011. 53(9):944-951. (IF=8.216)

9. 毛国顺,罗玲,刘晓琳,王丽春,刘利锋,邱志峰,韩扬,赵永,朱颖,谢静,李琦涵,李太生*.手足口病轻症与重症患者临床特征比较.中华传染病杂志,2008,26(7):387-390.(C100)

10. Li, TS#; Tubiana, R; Katlama, C; Calvez, V; AitMohand, H; Autran, B. Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. LANCET. 1998.351(9117): 1682-1686. (IF=47.831, C100)