吴文铭，1976年生，中国医学科学院北京协和医院（临床医学研究所）副院（所）长、党委常委，外科学教授，主任医师，博士生导师。2000年毕业于白求恩医科大学临床系临床医学专业。2005年毕业于中国协和医科大学外科学专业，获硕士学位。2010年毕业于北京协和医学院外科学专业，获博士学位。2017年获聘主任医师。2017-2019年任西藏自治区人民医院院长。担任中华医学会外科学分会全国委员，中国医师协会外科医师分会副会长。

专注胰腺病学和外科学的临床和进展，注重以先进前沿技术带动学科发展；关注胰腺肿瘤发生机制、肿瘤的早期诊断和早期筛查及胰腺外科手术新技术，开展临床及转化研究。

1. Zhao. W.#,Xu. Q., Yang J., Xie. XH., Li CM., Zhang. WH., Chen EH., Guo YF., Gao. MY., Shi. J., Zhang HB., Yao. H., Li. MX., Yan L., Fang. F., Wu. WM.*, Liu. XJ.* Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation. iSience 2022,10.1016/j.isci.2022.104544.(IF=6.1074)

2. Hua. S.#, Gao. J., Wang Z., Yeerkenbieke. P., Li. J., Wang J., He. G., Jiang. J., Lu. Y., Yu. Q., Han. X., Liao. Q., Wu. W*.Automatic bleeding detection in laparoscopic surgery based on a faster region-based convolutional neural network. Annals of Translational Medicine 2022,10.21 037/atm-22-1914. (IF=3.616)

3. Ling C#., Hong X., Xu M., Wang Y., Ma X., Cui Y., Jiang R., Cao D., Wu H., Tong A., Zhao Y., Wu W*. Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors. European journal of endocrinology 2022,10.1530/EJE-21-0893. (IF=6.558)

4. Wang, X#., Chen, H., Jiang, R., Hong, X., Peng, J., Chen, W., Jiang, J., Li, J., Huang, D., Dai, H., Wang, W., Lu, J., Zhao, Y.8, Wu, W*. Interleukin-17 activates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma. Cancer Letters 2021,508:1-12. (IF=9.756)

5. Wu W.#, Chen J., Bai C., Chi Y., Du Y., Feng S., Huo L., Jiang Y., Li J., Lou W., Luo J., Shao C., Shen L., Wang F., Wang L., Wang O., Wang Y., Wu H., Xing X., Xu J., Xue H., Xue L., Yang Y., Yu X., Yuan C., Zhao H., Zhu X., Zhao Y*. The Chinese guidelines for the diagnosis and treatment of pancreatic neuroendocrine neoplasms (2020). Journal of Pancreatology 2021,10.1097/JP9.0000000000000064.

6. Li Y.#, He Y., Peng J., Su Z., Li Z., Zhang B., Ma J., Zhuo M., Zou D., Liu X., Liu X., Wang W., Huang D., Xu M., Wang J., Deng H., Xue J., Xie W., Lan X., Chen M., Zhao Y., Wu W.*, David C.J*. Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer. Nature Cancer. 2021,10.1038/s43018-020-00134-z. (IF=23)

7. Hong, X#., Qiao, S., Li, F., Wang, W., Jiang, R., Wu, H., Chen, H., Liu, L., Peng, J., Wang, J., Jia, C., Liang, X., Dai, H., Jiang, J., Zhang, T., Liao, Q., Dai, M., Cong, L., Han, X., Guo, D., Liang, Z., Li, D., Zheng, Z., Ye, C., Li, S., Zhao, Y., Wu, K., Wu, W*. Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: Leading to a new classification system. Gut  2020, 69(5):877-887. (IF=31.84, R)

8. Peng, J#., Liu, L., Huang, D., Chen, H., Dai, M., Guo, J., Zhang, T., Liao, Q., Jiang, J., Wang, W., Guo, D., Cao, D., Xuan, Z., Li, D., Zhao, Y., Wu, W*. Impact of ischemia on sample quality of human pancreatic tissues. Pancreatology 2020, 20(2):265-277. (IF=3.977)

9. Dai, H#., Chen, H., Hong, X., Han, X., Xu, Q., Pang, H., Yuan, J., Wang, X., Xu, P., Jiang, J., Jiang, R., Zhuang, Z., Zhao, Y., Wu, W*. Early detection of cognitive impairment in patients with insulinoma. Endocrine 2019, 65(3):524-530. (IF=3.925)

10. Peng, J#., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., Yang, Y., Wang, W., Guo, D., Dai, M., Guo, J., Zhang, T., Liao, Q., Liu, Y., Zhao, Y.-L., Han, D.-L., Zhao, Y., Yang, Y.-G., Wu, W*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Research 2019, 29(9):(725-738), 10.1038/s41422-019-0195-y). Cell Research 29(9): 777. (IF=46.378, C100,  ESI)