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基础医学研究所

个人简介

王琳芳,1929年生,中国工程院院士,中国医学科学院基础医学研究所教授,博士生导师。1959年原北京协和医学院生化系研究生毕业。1960年至1961年赴前苏联莫斯科大科学院进修,回国后于中国医学科学院基础医学研究所生物化学与分子生物学研究室工作至今。1984-1992年任生物化学与分子生物学系系主任。 1992年至2004年任医学分子生物学国家重点实验室主任,现任医学分子生物学国家重点实验室名誉主任。


主要研究方向

以雄性生殖细胞为对象,从蛋白质/基因的结构与功能入手,探索其发生发展的分子机制及与相关重大疾病(不育与肿瘤)的关系。


代表性成果

1. Longchang Xu#, Yanlan Lu, Deqiang Han, Rongyan Yao, Han Wang, Shunshun Zhong, Yanyun luo, Ruiqin Han, Kai Li, Jun Fu, Shudong zong, Shiying Miao, Wei song*, Linfang Wang*. Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice. CELL DEATH DIS. 2017, 18; 8(5): e2795. (IF=5.638)

2. Wei Song#, Wenjie Liu#, HongZhao, Shangze Li, Xin Guan, Jianming Ying, Yefan Zhang, Xiaoxia Ren, FeiMiao, Mengmeng Zhang, Wenming Wu, Jun Fu, Junbo Liang, Wei Wu, Changzheng Liu, JiaYu, Shudong Zong, Shiying Miao, Xiaodong Zhang*, Linfang Wang*. RhomboidDomain Containing 1  (RHBDD1)  Promotes Colorectal Cancer Growth through Activation of the EGFR Signaling Pathway. Nature Communications. 2015, 6: 8022. (IF=11.329)

3. Jun Fu#, Yong Wang, Kin Lam Fok, Dantong Yang, Yi Qiu, Hsiao Chang Chan, Samuel S. Koide, Shiying Miao, and Linfang Wang*. Anti-ACTL7a antibodies: a cause of infertility. Fertility and Sterility. 2012,97(5): 1226-1233. (IF=3.958)

4. Ning Zhang#, Junbo Liang#, Yongqiang Tian, Ligang Yuan, Lan Wu, Shiying Miao, Shudong Zong, and Linfang Wang*. A novel testis specific GTPase serves as a link to proteasome biogenesis: functional characterization of RhoS/RSA-14-44 in spermatogenesis. Molecular Biology of the Cell. 2010,21:4312–43241. (IF=5.97)

5. Yong Wang#, Ning Zhang#, Xiaodong Zhang, Shiying Miao, Shudong Zong, S.S.Koide, and Linfang Wang*. Experimental Immunologic Infertility Effect of Anti-GAPDH-2 Antibodies on the Fertility of Female Mice. Fertility and Sterility. 2009,92(6)2020-2027. (IF=3.970)

6. Xueqian Yin#, Songying Ouyan#g, Wenming Xu#, Xiaopeng Zhang, Kin Lam Fok, Hau Yan Wong, Jiaping Zhang, Xiaobo Qiu,Shiying Miao, Hsiao Chang Chan* and Linfang wang*. YWK-II protein as a novel Go-coupled receptor for Müllerian Inhibiting Substance in cell survival. Journal of Cell Science. 2007, 120:1521-1528. (IF=6.383)

7. Yuan Qiao#, Ju Xiang Yang, Xiao Dong Zhang, Yu Liu, Jian Chao Zhang, Shu Dong Zong, Shi Ying Miao, Lin Fang Wang*, Samuel S. Koid*. Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis. Cell Research. 2004,14(3):197-207. (IF=1.729)

8. Gang Liang#, Xiaodong Zhang, Lujing Wang, Yushen Sha, Jianchao Zhang, Shiying Miao, Shudong Zong, Linfang Wang*, and S.S. Koide*. Identification of Differentially Expressed Genes of Primary Spermatocyte Against Round Spermatid Isolated from Human Testis Using the Laser Capture Microdissection Technique. Cell Research. 2004,14(6):507-512. (IF=1.936)

9. Shengwei Zou#, Jianchao Zhang, Xiaodong Zhang, Shiying Miao, Shudong Zong, Qi Sheng, Linfang Wang*. Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. Cell Reserch. 2003,13(3):171-177. (IF=1.729)

10. Yuanchang Yan#, Yun Bai, Lingfang Wang, Shiying Miao and Samuel S.Koide*. Characterization of cDNA Encoding a Human Sperm Membrane Protein Related to A4 Amyloid Protein. Proc Natl. Acad. Sci. 1990,87:2405-2408. (IF=9.040)