刘德培，1950年生，安徽阜南人，生物化学与分子生物学家，基础医学研究所研究员，博士生导师。1978年在湖南医科大学生物化学专业攻读硕士学位，从事生物化学研究。1984年在中国协和医科大学生物化学与分子生物学专业攻读博士学位，从事珠蛋白基因调控研究。1987年进入美国加州大学旧金山分校进行博士后研究工作，主要研究珠蛋白基因表达调控和基因治疗。1987年升为助理研究员，1989年为升副研究员，1992年升为研究员。

主要从事基因表达调控、基因治疗与心血管疾病发病机制研究。在深入研究疾病个性机制的基础上，运用系统性研究新思路新方法，探索重大疾病发生发展的共性危险因素和共性机制，为疾病防控提出干预的新策略。

1. Jian-Fei Pei#,Xun-Kai Li#,Wen-Qi Li#, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S Carroll,Jing Yang, Eric Erquan Zhang,Ji-Min Cao,Hou-Zao Chen*,De-Pei Liu*.Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks.Nat Cell Biol. 2019 Dec;21(12):1553-1564. (IF=28.824)

2. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity.Eur Heart J.2017 May 7;38(18):1389-1398. (IF=29.983，C100)

3. Yue Liu#, Ting-Ting Wang#, Ran Zhang#, Wen-Yan Fu, Xu Wang, Fang Wang, Peng Gao, Yang-Nan Ding, Yan Xie, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.Calorie restriction protects against experimental abdominal aortic aneurysms in mice.J Exp Med. 2016 Oct 17;213(11):2473-2488. (IF=14.307)

4. Hou-Zao Chen#, Fang Wang#, Peng Gao#, Jian-Fei Pei#, Yue Liu, Ting-Ting Xu, Xiaoqiang Tang, Wen-Yan Fu, Jie Lu, Yun-Fei Yan, Xiao-Man Wang, Lei Han, Zhu-Qin Zhang, Ran Zhang, Ming-Hui Zou, De-PeiLiu*.Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.Circ Res.2016 Oct 28;119(10):1076-1088. (IF=17.367, C100)

5. Guo-You Liu#, Guang-Nian Zhao#, Xiao-Feng Chen, De-Long Hao, Xiang Zhao, Xiang Lv*, De-Pei Liu*.The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster.Nucleic Acids Res. 2016 Apr 7;44(6):2613-27. (IF=16.971)

6. Ran Zhang#, Hou-Zao Chen*, De-Pei Liu*.The Four Layers of Aging.Cell Syst. 2015 Sep 23;1(3):180-6. (IF=10.304)

7. Jie Wu#, Li-Quan Zhou#, Wei Yu#, Zhi-Guo Zhao, Xue-Min Xie, Wen-Tian Wang, Jian Xiong, Man Li, Zheng Xue, Xing Wang, Peng Zhang, Bei-Bei Mao, De-Long Hao, Xiang Lv*, De-Pei Liu*.PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1.Blood. 2014 Jan 9;123(2):261-70. (IF=22.113)

8. Li Li#, Hui-Na Zhang#, Hou-Zao Chen#, Peng Gao, Li-Hua Zhu, Hong-Liang Li, Xiang Lv, Qing-Jun Zhang, Ran Zhang, Zhao Wang, Zhi-Gang She, Ran Zhang, Yu-Sheng Wei, Guan-Hua Du, De-Pei Liu*, Chih-Chuan Liang.SIRT1 acts as a modulator of neointima formation following vascular injury in mice.Circ Res. 2011 May 13;108(10):1180-9. (IF=17.367)

9. Shuang Zhou# , Hou-Zao Chen#, Yan-Zhen Wan#, Qing-Jun Zhang, Yu-Sheng Wei, Shuai Huang, Jin-Jing Liu, Yun-Biao Lu, Zhu-Qin Zhang, Rui-Feng Yang, Ran Zhang, Hua Cai, De-Pei Liu*, Chih-Chuan Liang.Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.Circ Res.2011 Sep 2;109(6):639-48. (IF=17.367)

10.Zhi-Gang She#, Wei Zheng, Yu-Sheng Wei, Hou-Zao Chen, Ai-Bing Wang, Hong-Liang Li, Guang Liu, Ran Zhang, Jin-Jing Liu, William B Stallcup, Zhongjun Zhou, De-Pei Liu*, Chih-Chuan Liang.Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice.Circ Res. 2009 May 22;104(10):1160-8. (IF=17.367)