张宏冰，1962年生，籍贯湖北，肿瘤生物学家，基础医学研究所研究员，博士生导师。1978年考入三峡大学临床医学专业，1982年获得学士学位。1985年在华中科技大学同济医学院外科专业攻读硕士学位，从事心血管病研究。1990年在宾夕法尼亚大学医学院病理学专业攻读博士学位，从事肿瘤研究。1998年进入NIH、哈佛大学医学院Brigham & Women’s 医院、DFCI研究所进行博士后研究工作，2004-2005年为讲师，主要研究肿瘤的发生机制与治疗。自2006年为中国医学科学院基础医学研究所-北京协和医学院基础学院教授。

从结节性硬化症、心肌病等罕见疾病到肝癌等常见疾病，探索雷帕霉素靶蛋白（mTOR）信号传导通路调节与疾病发生的机制和靶向治疗。针对疑难重症及罕见病，用mTOR抑制剂雷帕霉素（西罗莫司）老药新用开展多项临床试验。

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2. Zhou J#, Zhao Z#, Sun T#, Liu W, Yu Z, Liu J, Yu Y, Ning S*,Zhang H*. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study. Am J Gastroenterol. 2021 May 1;116(5):1044-1052. (IF= 12.045)

3. Chen X, # Wang Y#, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H*. mTORC1Upregulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice. Gastroenterology. 2015 Sep;149(3):741-52.e14. (IF=33.883)

4. Sun Q^#, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski DJ, Zhang H*. Mammalian target of rapamycin upregulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 2011 Mar 8;108(10):4129-34. (IF=12.779) (C100, F1000)

5. Zha X^#, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H*. Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res. 2011 Jan 1;71(1):13-8. (IF=13.312) (C100)

6. Mao Y^#*, Yang H, Xu H, Lu X, Sang X, Du S, Zhao H, Chen W, Xu Y, Chi T, Yang Z, Cai J, Li H, Chen J, Zhong S, Mohanti SR, Lopez-Soler R, Millis JM, Huang J, Zhang H. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut. 2010 Dec;59(12):1687-93. (IF=31.793) (C100)

7. Ma J^#, Meng Y^#, Kwiatkowsk DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Sun Q, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H*. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 2010, 120: 103-14. (IF=19.456) (C100)

8. Zhang H^#*, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGF receptors are critical for PI3K/AKT activation and negatively regulated by mTOR. J Clin Invest. 2007 Mar;117(3):730-8. (IF= 19.456) (C100)

9. Zhang H^#, Cicchetti G, Onda H, Koon HB, Asrikan K, Bajraszewski N, Vazquez P. Carpenter C, Kwiatkowski DJ.* Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signalling through downregulation of PDGFR. J Clin Invest. 2003 Oct;112(8):1223-33. (IF=19.456) (C100, F1000)

10. Kwiatkowski DJ^#*, Zhang H, Bandura JL, Heiberger KM, Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet. 2002 Mar 1;11(5):525-34. (IF=5.121) (C100)